![]() The trial included two cohorts that used different inclusion criteria to define high risk of recurrence. A systematic literature review identified the MonarchE trial, an ongoing, open-label, randomised, double blind trial involving 5637 people comparing abemaciclib in combination with ET versus ET alone. ![]() The ERG produced a critical review of the evidence for the clinical and cost-effectiveness evidence in the CS and also independently searched for relevant evidence and modified the manufacturer decision analytic model to examine the impact of altering some of the key assumptions. This paper summarised the Company Submission (CS), presents the ERG’s critical review of the clinical and cost-effectiveness evidence in the CS, highlights the key methodological considerations, and describes the development of the NICE guidance by the Appraisal Committee. Kleijnen Systematic Reviews Ltd, in combination with Newcastle University, was commissioned to act as the independent Evidence Review Group (ERG). We are an equal opportunity employer and considers all qualified applicants equally without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran status, or disability status.The National Institute for Health and Care Excellence (NICE) invited the manufacturer (Eli Lilly) of abemaciclib (Verzenios) to submit evidence for the clinical and cost effectiveness of this drug in combination with endocrine therapy (ET) for the treatment of adult patients with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-positive early breast cancer at high risk of recurrence, as part of the Institute’s Single Technology Appraisal (STA) process. Spectrum Academy provided the following inclusive hiring information: Physical ability to bend, lift, and carry at least 50 pounds.Physical ability to remain on feet for a minimum of 4 hours.Preferred: Experience with Special Education and IDEA requirements.Preferred: Experience with children with autism.Preferred: Minimum 2 years experience with behavior management.Preferred: RBT certification or willingness to obtain certification.Performs other duties as assigned by the Behavior Coordinator or Director of Related Services.Participates in in-service activities and staff meetings promoted by the School.Maintains current knowledge of Federal, State, and Local laws and regulations and abides by said laws and regulations with emphasis on persons with disabilities, child welfare, mental health, confidentiality, and student and parent rights.Maintains accurate case records and documentation.Adheres to and supports Board policy, School guidelines, and administrative rules and directives.Conducts student education and outreach opportunities, including assemblies and/or classroom instruction.Participates in family educational opportunities, including but not limited to Parent Empowerment Nights.Develops and provides professional development workshops as requested by the school Principal or Behavior Coordinator. ![]()
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